Primary Progressive Aphasia With Parkinsonism
Identifieur interne : 000829 ( Main/Exploration ); précédent : 000828; suivant : 000830Primary Progressive Aphasia With Parkinsonism
Auteurs : Karen M. Doherty [Royaume-Uni] ; Jonathan D. Rohrer [Royaume-Uni] ; Andrew Lees (neurologue) [Royaume-Uni] ; Janice L. Holton [Royaume-Uni] ; Jason Warren [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2013.
English descriptors
- KwdEn :
- Aged, Amyloid beta-Peptides (metabolism), Aphasia, Primary Progressive (etiology), Brain (pathology), Gait Disorders, Neurologic (etiology), Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Mental Status Schedule, Parkinsonian Disorders (complications), Parkinsonian Disorders (pathology), Writing, alpha-Synuclein (metabolism), tau Proteins (metabolism).
- MESH :
- chemical , metabolism : Amyloid beta-Peptides, alpha-Synuclein, tau Proteins.
- complications : Parkinsonian Disorders.
- etiology : Aphasia, Primary Progressive, Gait Disorders, Neurologic.
- pathology : Brain, Parkinsonian Disorders.
- Aged, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Mental Status Schedule, Writing.
Abstract
A 65-year-old man presented with word-finding difficulty and gait disturbance. His speech was nonfluent with word retrieval impairment and difficulties with sentence repetition. Other cognitive domains were intact initially. He developed asymmetrical bradykinesia, rigidity and a rest tremor. Over the following 8 years, his speech production impairment slowly deteriorated with the development of a motor speech disorder, anomia, impaired repetition of single words as well as sentences, and impaired comprehension of initially sentences then single words. His parkinsonian syndrome also deteriorated with limited response to levodopa. Serial brain MRI revealed progressive asymmetric perisylvian atrophy. He died after a disease duration of 12 years. The clinical syndrome is discussed by an expert, the pathology is described, and important clinical points from the case are highlighted. © 2013
Url:
DOI: 10.1002/mds.25341
PubMed: 23401267
PubMed Central: 3748791
Affiliations:
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Doherty</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology</institution><addr-line>London, UK</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology</institution><addr-line>London, UK</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Rohrer, Jonathan D" sort="Rohrer, Jonathan D" uniqKey="Rohrer J" first="Jonathan D" last="Rohrer">Jonathan D. Rohrer</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Dementia Research Center, UCL Institute of Neurology</institution><addr-line>London, UK</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew Lees (neurologue)</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology</institution><addr-line>London, UK</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology</institution><addr-line>London, UK</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author><author><name sortKey="Holton, Janice L" sort="Holton, Janice L" uniqKey="Holton J" first="Janice L" last="Holton">Janice L. Holton</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology</institution><addr-line>London, UK</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="au3"><institution>Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology</institution><addr-line>London, UK</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Warren, Jason" sort="Warren, Jason" uniqKey="Warren J" first="Jason" last="Warren">Jason Warren</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Dementia Research Center, UCL Institute of Neurology</institution><addr-line>London, UK</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author></analytic><series><title level="j">Movement Disorders</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Amyloid beta-Peptides (metabolism)</term><term>Aphasia, Primary Progressive (etiology)</term><term>Brain (pathology)</term><term>Gait Disorders, Neurologic (etiology)</term><term>Humans</term><term>Longitudinal Studies</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Mental Status Schedule</term><term>Parkinsonian Disorders (complications)</term><term>Parkinsonian Disorders (pathology)</term><term>Writing</term><term>alpha-Synuclein (metabolism)</term><term>tau Proteins (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Amyloid beta-Peptides</term><term>alpha-Synuclein</term><term>tau Proteins</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Aphasia, Primary Progressive</term><term>Gait Disorders, Neurologic</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Humans</term><term>Longitudinal Studies</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Mental Status Schedule</term><term>Writing</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A 65-year-old man presented with word-finding difficulty and gait disturbance. His speech was nonfluent with word retrieval impairment and difficulties with sentence repetition. Other cognitive domains were intact initially. He developed asymmetrical bradykinesia, rigidity and a rest tremor. Over the following 8 years, his speech production impairment slowly deteriorated with the development of a motor speech disorder, anomia, impaired repetition of single words as well as sentences, and impaired comprehension of initially sentences then single words. His parkinsonian syndrome also deteriorated with limited response to levodopa. Serial brain MRI revealed progressive asymmetric perisylvian atrophy. He died after a disease duration of 12 years. The clinical syndrome is discussed by an expert, the pathology is described, and important clinical points from the case are highlighted. © 2013 <italic>Movement</italic> Disorder Society</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Thal, Dr" uniqKey="Thal D">DR Thal</name></author><author><name sortKey="Rub, U" uniqKey="Rub U">U Rub</name></author><author><name sortKey="Orantes, M" uniqKey="Orantes M">M Orantes</name></author><author><name sortKey="Braak, H" uniqKey="Braak H">H Braak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Montine, Tj" uniqKey="Montine T">TJ Montine</name></author><author><name sortKey="Phelps, Ch" uniqKey="Phelps C">CH Phelps</name></author><author><name sortKey="Beach, Tg" uniqKey="Beach T">TG Beach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Braak, H" uniqKey="Braak H">H Braak</name></author><author><name sortKey="Del Tredici, K" uniqKey="Del Tredici K">K Del Tredici</name></author><author><name sortKey="Rub, U" uniqKey="Rub U">U Rub</name></author><author><name sortKey="De Vos, Ra" uniqKey="De Vos R">RA de Vos</name></author><author><name sortKey="Jansen Steur, En" uniqKey="Jansen Steur E">EN Jansen Steur</name></author><author><name sortKey="Braak, E" uniqKey="Braak E">E Braak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mckeith, Ig" uniqKey="Mckeith I">IG McKeith</name></author><author><name sortKey="Dickson, Dw" uniqKey="Dickson D">DW Dickson</name></author><author><name sortKey="Lowe, J" uniqKey="Lowe J">J Lowe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gorno Tempini, Ml" uniqKey="Gorno Tempini M">ML Gorno-Tempini</name></author><author><name sortKey="Hillis, Ae" uniqKey="Hillis A">AE Hillis</name></author><author><name sortKey="Weintraub, S" uniqKey="Weintraub S">S Weintraub</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williams Gray, Ch" uniqKey="Williams Gray C">CH Williams-Gray</name></author><author><name sortKey="Foltynie, T" uniqKey="Foltynie T">T Foltynie</name></author><author><name sortKey="Brayne, Ce" uniqKey="Brayne C">CE Brayne</name></author><author><name sortKey="Robbins, Tw" uniqKey="Robbins T">TW Robbins</name></author><author><name sortKey="Barker, Ra" uniqKey="Barker R">RA Barker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bastiaanse, R" uniqKey="Bastiaanse R">R Bastiaanse</name></author><author><name sortKey="Leenders, Kl" uniqKey="Leenders K">KL Leenders</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rohrer, Jd" uniqKey="Rohrer J">JD Rohrer</name></author><author><name sortKey="Lashley, T" uniqKey="Lashley T">T Lashley</name></author><author><name sortKey="Schott, Jm" uniqKey="Schott J">JM Schott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rohrer, Jd" uniqKey="Rohrer J">JD Rohrer</name></author><author><name sortKey="Schott, Jm" uniqKey="Schott J">JM Schott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rohrer, Jd" uniqKey="Rohrer J">JD Rohrer</name></author><author><name sortKey="Rossor, Mn" uniqKey="Rossor M">MN Rossor</name></author><author><name sortKey="Warren, Jd" uniqKey="Warren J">JD Warren</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gorno Tempini, Ml" uniqKey="Gorno Tempini M">ML Gorno-Tempini</name></author><author><name sortKey="Dronkers, Nf" uniqKey="Dronkers N">NF Dronkers</name></author><author><name sortKey="Rankin, Kp" uniqKey="Rankin K">KP Rankin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kremen, Sa" uniqKey="Kremen S">SA Kremen</name></author><author><name sortKey="Mendez, Mf" uniqKey="Mendez M">MF Mendez</name></author><author><name sortKey="Tsai, Ph" uniqKey="Tsai P">PH Tsai</name></author><author><name sortKey="Teng, E" uniqKey="Teng E">E Teng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ling, H" uniqKey="Ling H">H Ling</name></author><author><name sortKey="O Sullivan, Ss" uniqKey="O Sullivan S">SS O'Sullivan</name></author><author><name sortKey="Holton, Jl" uniqKey="Holton J">JL Holton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snowden, Js" uniqKey="Snowden J">JS Snowden</name></author><author><name sortKey="Stopford, Cl" uniqKey="Stopford C">CL Stopford</name></author><author><name sortKey="Julien, Cl" uniqKey="Julien C">CL Julien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hughes, Aj" uniqKey="Hughes A">AJ Hughes</name></author><author><name sortKey="Daniel, Se" uniqKey="Daniel S">SE Daniel</name></author><author><name sortKey="Lees, Aj" uniqKey="Lees A">AJ Lees</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>National Hospital for Neurology and Neurosurgery</li></orgName></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Doherty, Karen M" sort="Doherty, Karen M" uniqKey="Doherty K" first="Karen M" last="Doherty">Karen M. Doherty</name></noRegion><name sortKey="Doherty, Karen M" sort="Doherty, Karen M" uniqKey="Doherty K" first="Karen M" last="Doherty">Karen M. Doherty</name><name sortKey="Holton, Janice L" sort="Holton, Janice L" uniqKey="Holton J" first="Janice L" last="Holton">Janice L. Holton</name><name sortKey="Holton, Janice L" sort="Holton, Janice L" uniqKey="Holton J" first="Janice L" last="Holton">Janice L. Holton</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew Lees (neurologue)</name><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J" last="Lees">Andrew Lees (neurologue)</name><name sortKey="Rohrer, Jonathan D" sort="Rohrer, Jonathan D" uniqKey="Rohrer J" first="Jonathan D" last="Rohrer">Jonathan D. Rohrer</name><name sortKey="Warren, Jason" sort="Warren, Jason" uniqKey="Warren J" first="Jason" last="Warren">Jason Warren</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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